Intramolecular base–backbone association in 8-bromo-2′,3′-O-isopropylidene-adenosine. Detection of an O(5′)–H ⋯ N(3) hydrogen bond via a long range H(5″)–N(3) spin–spin coupling
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چکیده
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Intramolecular hydrogen bond in biologically active o-carbonyl hydroquinones.
Intramolecular hydrogen bonds (IHBs) play a central role in the molecular structure, chemical reactivity and interactions of biologically active molecules. Here, we study the IHBs of seven related o-carbonyl hydroquinones and one structurally-related aromatic lactone, some of which have shown anticancer and antioxidant activity. Experimental NMR data were correlated with theoretical calculation...
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Infrared-ultraviolet double resonance spectroscopy has been applied to study the infrared spectra of the supersonically cooled gas phase complexes of formic acid, acetic acid, propionic acid, formamide, and water with 9-hydroxy-9-fluorenecarboxylic acid (9HFCA), an analog of glycolic acid. In these complexes each binding partner to 9HFCA can function as both proton donor and acceptor. Relative ...
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A series of conformationally restricted triol and tetrol systems containing intramolecular hydrogen bond arrays has been prepared and characterized by X-ray crystallography and NMR spectroscopy. NMR isotopic perturbation measurements in DMSO-d6 and CD2Cl2 reveal that this methodology can be used to detect the spatial proximity of up to four contiguous hydroxyl groups sharing a 1,3-, 1,4-, or 1,...
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Since the discovery of NMR coupling constants across hydrogen bonds A H···B containing nuclei with spin =2, such as A, B= F, N, it has been established that these NMR parameters can not only be used to detect hydrogen bridges in biomolecules but also to determine the geometries of strong hydrogen bonds in solution. It has been shown experimentally and by ab initio calculations that scalar two-b...
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We report the formation of a highly unusual fused, tricyclic purine derivative via N3 alkylation of 9-propargyladenine, upon activation of the acetylenic triple bond by Ag(I) ions. The participation of silver ions in this process might offer newer design paradigms for minor groove N3 DNA alkylation, antibacterial and anticancer agents.
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ژورنال
عنوان ژورنال: J. Chem. Soc., Chem. Commun.
سال: 1986
ISSN: 0022-4936
DOI: 10.1039/c39860000362